Genetic Diversity of Circulating Genotypes of PCR Confirmed <i>Neisseria meningitidis</i> Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria

Iseimokumo Christopher Peletiri; Grace Mebi Ayanbimpe; Eugene Ifeanyichukwu Ikeh

doi:doi:10.11648/j.ijmb.20220702.11

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Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria

Iseimokumo Christopher Peletiri, Grace Mebi Ayanbimpe, Eugene Ifeanyichukwu Ikeh

Published in International Journal of Microbiology and Biotechnology (Volume 7, Issue 2)

Received: 24 February 2022 Accepted: 17 March 2022 Published: 9 April 2022

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Abstract

The genetic potential of an organism is carried in the base sequence of its DNA according to the genetic code. Just as we have defined genotypes in humans, bacterial genotypes are specific and defined too. However, information on circulating N. meningitidis genotypes from northern Nigeria are unavailable in literature. Molecular genotyping methods are used to address two very different kinds of problems associated with disease outbreak (short term or local epidemiology and long term or global epidemiology). The multilocus sequence typing scheme developed for N. meningitidis which is based on DNA sequencing of segments of seven housekeeping loci was used being the gold standard. The PubMLST.org database and Bacterial Isolate Genome Sequence Database software were equally used. Of the 40 genotyped samples, 31 (77.5%) had detectable genotypes; genotype abcZ in three cases (7.5%); adk, four (10%); aroE, three (7.5%); fumC, 16 (40%); pdhC, two (5%); and genotype pdh in three cases (7.5%). The six genotypes encountered were found to be circulating amongst the various serogroups in parts of northern Nigeria which is now publicly reported in literature for the first time in Nigeria. Genotype abcZ was found circulating amongst serogroups A (sacB) and Y (synF); genotype adk amongst serogroups A (sacB), W135 (synG), and Y (synF); genotype aroE amongst serogroups C (synE), W135 (synG), and Y (synF); genotype fumC amongst serogroups A (sacB), B (synD), C (synE), W135 (synG), X (xcbB), and Y (synF); genotype pdhC amongst serogroups B (synD), and X (xcbB); and genotype pgm amongst serogroups B (synD), C (synE), and Y (synF). The utilization of our findings by health authorities would be of great importance for public health strategies such as vaccination. Our knowledge has been widened to acknowledge the presence of bacterial genotypes circulating amongst various N. meningitidis serogroups.

Published in	International Journal of Microbiology and Biotechnology (Volume 7, Issue 2)
DOI	10.11648/j.ijmb.20220702.11
Page(s)	51-57
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Genetic Diversity, Bacterial Genotypes, Serogroups, N. meningitidis, CSM, Northern Nigeria

References

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Iseimokumo Christopher Peletiri, Grace Mebi Ayanbimpe, Eugene Ifeanyichukwu Ikeh. (2022). Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria. International Journal of Microbiology and Biotechnology, 7(2), 51-57. https://doi.org/10.11648/j.ijmb.20220702.11

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Iseimokumo Christopher Peletiri; Grace Mebi Ayanbimpe; Eugene Ifeanyichukwu Ikeh. Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria. Int. J. Microbiol. Biotechnol. 2022, 7(2), 51-57. doi: 10.11648/j.ijmb.20220702.11

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AMA Style

Iseimokumo Christopher Peletiri, Grace Mebi Ayanbimpe, Eugene Ifeanyichukwu Ikeh. Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria. Int J Microbiol Biotechnol. 2022;7(2):51-57. doi: 10.11648/j.ijmb.20220702.11

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@article{10.11648/j.ijmb.20220702.11,
  author = {Iseimokumo Christopher Peletiri and Grace Mebi Ayanbimpe and Eugene Ifeanyichukwu Ikeh},
  title = {Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria},
  journal = {International Journal of Microbiology and Biotechnology},
  volume = {7},
  number = {2},
  pages = {51-57},
  doi = {10.11648/j.ijmb.20220702.11},
  url = {https://doi.org/10.11648/j.ijmb.20220702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmb.20220702.11},
  abstract = {The genetic potential of an organism is carried in the base sequence of its DNA according to the genetic code. Just as we have defined genotypes in humans, bacterial genotypes are specific and defined too. However, information on circulating N. meningitidis genotypes from northern Nigeria are unavailable in literature. Molecular genotyping methods are used to address two very different kinds of problems associated with disease outbreak (short term or local epidemiology and long term or global epidemiology). The multilocus sequence typing scheme developed for N. meningitidis which is based on DNA sequencing of segments of seven housekeeping loci was used being the gold standard. The PubMLST.org database and Bacterial Isolate Genome Sequence Database software were equally used. Of the 40 genotyped samples, 31 (77.5%) had detectable genotypes; genotype abcZ in three cases (7.5%); adk, four (10%); aroE, three (7.5%); fumC, 16 (40%); pdhC, two (5%); and genotype pdh in three cases (7.5%). The six genotypes encountered were found to be circulating amongst the various serogroups in parts of northern Nigeria which is now publicly reported in literature for the first time in Nigeria. Genotype abcZ was found circulating amongst serogroups A (sacB) and Y (synF); genotype adk amongst serogroups A (sacB), W135 (synG), and Y (synF); genotype aroE amongst serogroups C (synE), W135 (synG), and Y (synF); genotype fumC amongst serogroups A (sacB), B (synD), C (synE), W135 (synG), X (xcbB), and Y (synF); genotype pdhC amongst serogroups B (synD), and X (xcbB); and genotype pgm amongst serogroups B (synD), C (synE), and Y (synF). The utilization of our findings by health authorities would be of great importance for public health strategies such as vaccination. Our knowledge has been widened to acknowledge the presence of bacterial genotypes circulating amongst various N. meningitidis serogroups.},
 year = {2022}
}

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TY  - JOUR
T1  - Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria
AU  - Iseimokumo Christopher Peletiri
AU  - Grace Mebi Ayanbimpe
AU  - Eugene Ifeanyichukwu Ikeh
Y1  - 2022/04/09
PY  - 2022
N1  - https://doi.org/10.11648/j.ijmb.20220702.11
DO  - 10.11648/j.ijmb.20220702.11
T2  - International Journal of Microbiology and Biotechnology
JF  - International Journal of Microbiology and Biotechnology
JO  - International Journal of Microbiology and Biotechnology
SP  - 51
EP  - 57
PB  - Science Publishing Group
SN  - 2578-9686
UR  - https://doi.org/10.11648/j.ijmb.20220702.11
AB  - The genetic potential of an organism is carried in the base sequence of its DNA according to the genetic code. Just as we have defined genotypes in humans, bacterial genotypes are specific and defined too. However, information on circulating N. meningitidis genotypes from northern Nigeria are unavailable in literature. Molecular genotyping methods are used to address two very different kinds of problems associated with disease outbreak (short term or local epidemiology and long term or global epidemiology). The multilocus sequence typing scheme developed for N. meningitidis which is based on DNA sequencing of segments of seven housekeeping loci was used being the gold standard. The PubMLST.org database and Bacterial Isolate Genome Sequence Database software were equally used. Of the 40 genotyped samples, 31 (77.5%) had detectable genotypes; genotype abcZ in three cases (7.5%); adk, four (10%); aroE, three (7.5%); fumC, 16 (40%); pdhC, two (5%); and genotype pdh in three cases (7.5%). The six genotypes encountered were found to be circulating amongst the various serogroups in parts of northern Nigeria which is now publicly reported in literature for the first time in Nigeria. Genotype abcZ was found circulating amongst serogroups A (sacB) and Y (synF); genotype adk amongst serogroups A (sacB), W135 (synG), and Y (synF); genotype aroE amongst serogroups C (synE), W135 (synG), and Y (synF); genotype fumC amongst serogroups A (sacB), B (synD), C (synE), W135 (synG), X (xcbB), and Y (synF); genotype pdhC amongst serogroups B (synD), and X (xcbB); and genotype pgm amongst serogroups B (synD), C (synE), and Y (synF). The utilization of our findings by health authorities would be of great importance for public health strategies such as vaccination. Our knowledge has been widened to acknowledge the presence of bacterial genotypes circulating amongst various N. meningitidis serogroups.
VL  - 7
IS  - 2
ER  -

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Author Information

Iseimokumo Christopher Peletiri

Department of Medical Microbiology, Faculty of Clinical Sciences, College of Health Sciences, University of Jos, Jos, Nigeria
Grace Mebi Ayanbimpe

Department of Medical Microbiology, Faculty of Clinical Sciences, College of Health Sciences, University of Jos, Jos, Nigeria
Eugene Ifeanyichukwu Ikeh

Department of Medical Microbiology, Faculty of Clinical Sciences, College of Health Sciences, University of Jos, Jos, Nigeria

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Iseimokumo Christopher Peletiri, Grace Mebi Ayanbimpe, Eugene Ifeanyichukwu Ikeh. (2022). Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria. International Journal of Microbiology and Biotechnology, 7(2), 51-57. https://doi.org/10.11648/j.ijmb.20220702.11

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Iseimokumo Christopher Peletiri; Grace Mebi Ayanbimpe; Eugene Ifeanyichukwu Ikeh. Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria. Int. J. Microbiol. Biotechnol. 2022, 7(2), 51-57. doi: 10.11648/j.ijmb.20220702.11

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AMA Style

Iseimokumo Christopher Peletiri, Grace Mebi Ayanbimpe, Eugene Ifeanyichukwu Ikeh. Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria. Int J Microbiol Biotechnol. 2022;7(2):51-57. doi: 10.11648/j.ijmb.20220702.11

Copy | Download

@article{10.11648/j.ijmb.20220702.11,
  author = {Iseimokumo Christopher Peletiri and Grace Mebi Ayanbimpe and Eugene Ifeanyichukwu Ikeh},
  title = {Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria},
  journal = {International Journal of Microbiology and Biotechnology},
  volume = {7},
  number = {2},
  pages = {51-57},
  doi = {10.11648/j.ijmb.20220702.11},
  url = {https://doi.org/10.11648/j.ijmb.20220702.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmb.20220702.11},
  abstract = {The genetic potential of an organism is carried in the base sequence of its DNA according to the genetic code. Just as we have defined genotypes in humans, bacterial genotypes are specific and defined too. However, information on circulating N. meningitidis genotypes from northern Nigeria are unavailable in literature. Molecular genotyping methods are used to address two very different kinds of problems associated with disease outbreak (short term or local epidemiology and long term or global epidemiology). The multilocus sequence typing scheme developed for N. meningitidis which is based on DNA sequencing of segments of seven housekeeping loci was used being the gold standard. The PubMLST.org database and Bacterial Isolate Genome Sequence Database software were equally used. Of the 40 genotyped samples, 31 (77.5%) had detectable genotypes; genotype abcZ in three cases (7.5%); adk, four (10%); aroE, three (7.5%); fumC, 16 (40%); pdhC, two (5%); and genotype pdh in three cases (7.5%). The six genotypes encountered were found to be circulating amongst the various serogroups in parts of northern Nigeria which is now publicly reported in literature for the first time in Nigeria. Genotype abcZ was found circulating amongst serogroups A (sacB) and Y (synF); genotype adk amongst serogroups A (sacB), W135 (synG), and Y (synF); genotype aroE amongst serogroups C (synE), W135 (synG), and Y (synF); genotype fumC amongst serogroups A (sacB), B (synD), C (synE), W135 (synG), X (xcbB), and Y (synF); genotype pdhC amongst serogroups B (synD), and X (xcbB); and genotype pgm amongst serogroups B (synD), C (synE), and Y (synF). The utilization of our findings by health authorities would be of great importance for public health strategies such as vaccination. Our knowledge has been widened to acknowledge the presence of bacterial genotypes circulating amongst various N. meningitidis serogroups.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Genetic Diversity of Circulating Genotypes of PCR Confirmed Neisseria meningitidis Serogroups Amongst Cerebrospinal Meningitis Patients in Parts of Northern Nigeria
AU  - Iseimokumo Christopher Peletiri
AU  - Grace Mebi Ayanbimpe
AU  - Eugene Ifeanyichukwu Ikeh
Y1  - 2022/04/09
PY  - 2022
N1  - https://doi.org/10.11648/j.ijmb.20220702.11
DO  - 10.11648/j.ijmb.20220702.11
T2  - International Journal of Microbiology and Biotechnology
JF  - International Journal of Microbiology and Biotechnology
JO  - International Journal of Microbiology and Biotechnology
SP  - 51
EP  - 57
PB  - Science Publishing Group
SN  - 2578-9686
UR  - https://doi.org/10.11648/j.ijmb.20220702.11
AB  - The genetic potential of an organism is carried in the base sequence of its DNA according to the genetic code. Just as we have defined genotypes in humans, bacterial genotypes are specific and defined too. However, information on circulating N. meningitidis genotypes from northern Nigeria are unavailable in literature. Molecular genotyping methods are used to address two very different kinds of problems associated with disease outbreak (short term or local epidemiology and long term or global epidemiology). The multilocus sequence typing scheme developed for N. meningitidis which is based on DNA sequencing of segments of seven housekeeping loci was used being the gold standard. The PubMLST.org database and Bacterial Isolate Genome Sequence Database software were equally used. Of the 40 genotyped samples, 31 (77.5%) had detectable genotypes; genotype abcZ in three cases (7.5%); adk, four (10%); aroE, three (7.5%); fumC, 16 (40%); pdhC, two (5%); and genotype pdh in three cases (7.5%). The six genotypes encountered were found to be circulating amongst the various serogroups in parts of northern Nigeria which is now publicly reported in literature for the first time in Nigeria. Genotype abcZ was found circulating amongst serogroups A (sacB) and Y (synF); genotype adk amongst serogroups A (sacB), W135 (synG), and Y (synF); genotype aroE amongst serogroups C (synE), W135 (synG), and Y (synF); genotype fumC amongst serogroups A (sacB), B (synD), C (synE), W135 (synG), X (xcbB), and Y (synF); genotype pdhC amongst serogroups B (synD), and X (xcbB); and genotype pgm amongst serogroups B (synD), C (synE), and Y (synF). The utilization of our findings by health authorities would be of great importance for public health strategies such as vaccination. Our knowledge has been widened to acknowledge the presence of bacterial genotypes circulating amongst various N. meningitidis serogroups.
VL  - 7
IS  - 2
ER  -

Copy | Download